Solid dispersion of acetaminophen and poly(ethylene oxide) prepared by hot-melt mixing

Document Type

Article

Publication Date

8-1-2010

Abstract

In this study, a model drug, acetaminophen (APAP), was melt mixed with poly(ethylene oxide) (PEO) using a Brabender mixer. APAP was found to recrystallize upon cooling to room temperature for all the drug loadings investigated. Higher drug loading leads to faster recrystallization rate. However, the morphology of the recrystallized drug crystals is identical in samples with different drug loadings and does not change with the storage time. To adjust the drug's dissolution rate, nanoclay Cloisite® 15A and 30B were added into the binary mixture. The presence of either of the nanoclay dramatically accelerates the drug's recrystallization rate and slows down the drug's releasing rate. The drop of the releasing rate is mainly due to the decrease of wettability, as supported by the contact angle data. Data analysis of the dissolution results suggests that the addition of nanoclays changes the drug's release mechanism from erosion dominant to diffusion dominant. This study suggests that nanoclays may be utilized to tailor the drug's releasing rate and to improve the dosage form's stability by dramatically shortening the lengthy recrystallization process. © 2010 Elsevier B.V.

Identifier

77954310058 (Scopus)

Publication Title

International Journal of Pharmaceutics

External Full Text Location

https://doi.org/10.1016/j.ijpharm.2010.04.033

ISSN

03785173

PubMed ID

20435110

First Page

53

Last Page

61

Issue

1-2

Volume

395

Grant

CMMI-0927142

Fund Ref

National Science Foundation

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