Depth-dependent hemoglobin analysis from multispectral transillumination images

Document Type

Article

Publication Date

10-1-2010

Abstract

Multispectral transillumination imaging is a promisingmodality for noninvasive imaging of living tissue. Multispectral Nevoscope imaging is directed toward the imaging of skin lesions for the detection and characterization of skin cancers through the volumetric analysis of selected chromophores, such as melanin, oxy-, and deoxyhemoglobin. In this letter, we present a novel method of recovering depth-dependent measurements from transilluminationimages obtained through the Nevoscope. A method for estimating the depth-dependent point spread function is presented and used in recovering multispectral transillumination images of a skin phantom or lesion through blind deconvolution. A method for ratiometric analysis for the quantification of oxyand deoxyhemoglobin is then presented and evaluated on a skin phantom. The presented methods would allow reliable quantitative analysis of multispectral Nevoscope images for early detection of angiogenesis leading to early diagnosis of skin cancers. © 2010 IEEE.

Identifier

77956921026 (Scopus)

Publication Title

IEEE Transactions on Biomedical Engineering

External Full Text Location

https://doi.org/10.1109/TBME.2010.2059025

ISSN

00189294

PubMed ID

20639166

First Page

2568

Last Page

2571

Issue

10 PART 2

Volume

57

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