Fibrous scaffolds for bone tissue engineering

Document Type

Syllabus

Publication Date

1-1-2020

Abstract

More than 1 million orthopedic procedures are performed in the U.S. each year, for reconstructive surgery, trauma, or abnormal skeletal defects. Bone grafts are typically used in these procedures. However, due to current limitations with bone grafts, autografts, and allografts, bone tissue engineering strategies have been sought. Bone tissue engineering uses cells and/or growth factors in combination with biomaterials that act as scaffolds to repair bone tissue. Fiber-containing scaffolds are of interest because they mimic the structure of the native collagen matrix in the bone ECM. Fibers provide a surface conducive for cellular attachment, growth, and other cellular behaviors that are favorable for bone tissue formation. This chapter will review bone biology, processing techniques commonly used to prepare fibrous scaffolds, and recent advances using fibrous scaffolds for bone tissue engineering application.

Identifier

85117945604 (Scopus)

ISBN

[9780081028506]

Publication Title

Artificial Protein and Peptide Nanofibers Design Fabrication Characterization and Applications

External Full Text Location

https://doi.org/10.1016/B978-0-08-102850-6.00015-2

First Page

351

Last Page

382

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