Metal-Organic Framework-Based Microfluidic Impedance Sensor Platform for Ultrasensitive Detection of Perfluorooctanesulfonate
Document Type
Article
Publication Date
3-4-2020
Abstract
The growing global concerns to public health from human exposure to perfluorooctanesulfonate (PFOS) require rapid, sensitive, in situ detection where current, state-of-the-art techniques are yet to adequately meet sensitivity standards of the real world. This work presents, for the first time, a synergistic approach for the targeted affinity-based capture of PFOS using a porous sorbent probe that enhances detection sensitivity by embedding it on a microfluidic platform. This novel sorbent-containing platform functions as an electrochemical sensor to directly measure PFOS concentration through a proportional change in electrical current (increase in impedance). The extremely high surface area and pore volume of mesoporous metal-organic framework (MOF) Cr-MIL-101 is used as the probe for targeted PFOS capture based on the affinity of the chromium center toward both the fluorine tail groups as well as the sulfonate functionalities as demonstrated by spectroscopic (NMR and XPS) and microscopic (TEM) studies. Answering the need for an ultrasensitive PFOS detection technique, we are embedding the MOF capture probes inside a microfluidic channel, sandwiched between interdigitated microelectrodes (IDμE). The nanoporous geometry, along with interdigitated microelectrodes, increases the signal-to-noise ratio tremendously. Further, the ability of the capture probes to interact with the PFOS at the molecular level and effectively transduce that response electrochemically has allowed us achieve a significant increase in sensitivity. The PFOS detection limit of 0.5 ng/L is unprecedented for in situ analytical PFOS sensors and comparable to quantification limits achieved using state-of-the-art ex situ techniques.
Identifier
85080056422 (Scopus)
Publication Title
ACS Applied Materials and Interfaces
External Full Text Location
https://doi.org/10.1021/acsami.9b22445
e-ISSN
19448252
ISSN
19448244
PubMed ID
32031779
First Page
10503
Last Page
10514
Issue
9
Volume
12
Grant
1751759
Fund Ref
National Science Foundation
Recommended Citation
Cheng, Yu H.; Barpaga, Dushyant; Soltis, Jennifer A.; Shutthanandan, V.; Kargupta, Roli; Han, Kee Sung; McGrail, B. Peter; Motkuri, Radha Kishan; Basuray, Sagnik; and Chatterjee, Sayandev, "Metal-Organic Framework-Based Microfluidic Impedance Sensor Platform for Ultrasensitive Detection of Perfluorooctanesulfonate" (2020). Faculty Publications. 5419.
https://digitalcommons.njit.edu/fac_pubs/5419
