Role of Cholesterol on Binding of Amyloid Fibrils to Lipid Bilayers

Authors

Cristiano L. Dias, New Jersey Institute of Technology
Sharareh Jalali, New Jersey Institute of Technology
Yanxing Yang, New Jersey Institute of Technology
Luis Cruz, Drexel University

Document Type

Article

Publication Date

4-16-2020

Abstract

Molecular dynamics simulations are used to provide insights into the molecular mechanisms accounting for binding of amyloid fibrils to lipid bilayers and to study the effect of cholesterol in this process. We show that electrostatic interactions play an important role in fibril-bilayer binding and cholesterol modulates this interaction. In particular, the interaction between positive residues and lipid head groups becomes more favorable in the presence of cholesterol. Consistent with experiments, we find that cholesterol enhances fibril-membrane binding.

Identifier

85083544996 (Scopus)

Publication Title

Journal of Physical Chemistry B

External Full Text Location

https://doi.org/10.1021/acs.jpcb.0c00485

e-ISSN

15205207

ISSN

15206106

PubMed ID

32207622

First Page

3036

Last Page

3042

Issue

15

Volume

124

Grant

CHE-1904364

Fund Ref

National Science Foundation

Recommended Citation

Dias, Cristiano L.; Jalali, Sharareh; Yang, Yanxing; and Cruz, Luis, "Role of Cholesterol on Binding of Amyloid Fibrils to Lipid Bilayers" (2020). Faculty Publications. 5352.
https://digitalcommons.njit.edu/fac_pubs/5352