Exploiting biomechanics to direct the formation of nervous tissue

Document Type

Article

Publication Date

6-1-2020

Abstract

Forces and displacements play essential roles in the development and maintenance of all living organisms. The biomechanics in living systems includes traction in cell motility, motor proteins driving cellular transport, tensegrity of the cytoskeleton, and mechanotransduction of signal pathways. In the past few decades, we have learned a great deal about how biomechanics is important in the development, maintenance, and repair of the nervous system. In this review, we critically assess recent advances in using mechanical stimuli toward exploiting the directed growth and formation of nervous tissues. We discuss current systems that recapitulate the mechanical environment surrounding neural tissues as engineering solutions to explore the relationship forces play in modifying neurons and their processes, as well as exploit these processes to enhance regeneration and repair.

Identifier

85088639700 (Scopus)

Publication Title

Current Opinion in Biomedical Engineering

External Full Text Location

https://doi.org/10.1016/j.cobme.2020.05.009

e-ISSN

24684511

First Page

59

Last Page

66

Volume

14

Grant

CBET-0747615

Fund Ref

National Science Foundation

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