Test-retest of a phoria adaptation stimulus-induced functional MRI experiment

Document Type

Article

Publication Date

8-1-2020

Abstract

This study was designed to identify the neural substrates activated during a phoria adaptation task using functional magnetic resonance imaging (MRI) in young adults with normal binocular vision and to test the repeatability of the fMRI measurements for this protocol. The phoria adaptation task consisted of a block protocol of 90 seconds of near visual crossed fixation followed by 90 seconds of far visual uncrossed fixation, repeated three times; the data were collected during two different experimental sessions. Results showed that the oculomotor vermis, cuneus, and primary visual cortex had the greatest functional activity within the regions of interest studied when stimulated by the phoria adaptation task. The oculomotor vermis functional activity had an intraclass correlation coefficient (ICC) of 0.3, whereas the bilateral cuneus and primary visual cortex had good ICC results of greater than 0.6. These results suggest that the sustained visual fixation task described within this study reliably activates the neural substrates of phoria adaptation. This protocol establishes a methodology that can be used in future longitudinal studies investigating therapeutic interventions that may modify phoria adaptation.

Identifier

85089534293 (Scopus)

Publication Title

Journal of Vision

External Full Text Location

https://doi.org/10.1167/JOV.20.8.17

e-ISSN

15347362

PubMed ID

32797193

First Page

1

Last Page

15

Issue

8

Volume

20

Grant

R01EY023261

Fund Ref

National Eye Institute

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