Intersubject consistent dynamic connectivity during natural vision revealed by functional MRI
Document Type
Article
Publication Date
8-1-2020
Abstract
The functional communications between brain regions are thought to be dynamic. However, it is usually difficult to elucidate whether the observed dynamic connectivity is functionally meaningful or simply due to noise during unconstrained task conditions such as resting-state. During naturalistic conditions, such as watching a movie, it has been shown that local brain activities, e.g. in the visual cortex, are consistent across subjects. Following similar logic, we propose to study intersubject correlations of the time courses of dynamic connectivity during naturalistic conditions to extract functionally meaningful dynamic connectivity patterns. We analyzed a functional MRI (fMRI) dataset when the subjects watched a short animated movie. We calculated dynamic connectivity by using sliding window technique, and quantified the intersubject correlations of the time courses of dynamic connectivity. Although the time courses of dynamic connectivity are thought to be noisier than the original signals, we found similar level of intersubject correlations of dynamic connectivity to those of regional activity. Most importantly, highly consistent dynamic connectivity could occur between regions that did not show high intersubject correlations of regional activity, and between regions with little stable functional connectivity. The analysis highlighted higher order brain regions such as the default mode network that dynamically interacted with posterior visual regions during the movie watching, which may be associated with the understanding of the movie.
Identifier
85081980185 (Scopus)
Publication Title
Neuroimage
External Full Text Location
https://doi.org/10.1016/j.neuroimage.2020.116698
e-ISSN
10959572
ISSN
10538119
PubMed ID
32130972
Volume
216
Grant
R01 AT009829
Fund Ref
National Institute on Drug Abuse
Recommended Citation
Di, Xin and Biswal, Bharat B., "Intersubject consistent dynamic connectivity during natural vision revealed by functional MRI" (2020). Faculty Publications. 5107.
https://digitalcommons.njit.edu/fac_pubs/5107
