Implantable anti-angiogenic scaffolds for treatment of neovascular ocular pathologies

Document Type

Article

Publication Date

10-1-2020

Abstract

The retinal physiology can accrue oxidative damage and inflammatory insults due to age and metabolic irregularities. Two notable diseases that involve retinal and choroidal neovascularization are proliferative diabetic retinopathy and wet age-related macular degeneration. Currently, these diseases are mainly treated with anti-VEGF drugs (VEGF = vascular endothelial growth factor), generally on a monthly dosage scheme. We discuss recent developments for the treatment of these diseases, including bioactive tissue-engineered materials, which may reduce frequency of dosage and propose a path forward for improving patient outcomes. [Figure not available: see fulltext.]

Identifier

85083099767 (Scopus)

Publication Title

Drug Delivery and Translational Research

External Full Text Location

https://doi.org/10.1007/s13346-020-00753-0

e-ISSN

21903948

ISSN

2190393X

PubMed ID

32232681

First Page

1191

Last Page

1202

Issue

5

Volume

10

Grant

IIP 1903617

Fund Ref

National Science Foundation

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