Altered Spatial Organization of Dynamic Functional Network Associates With Deficient Sensory and Perceptual Network in Schizophrenia

Authors

Hui He, University of Electronic Science and Technology of China
Cheng Luo, University of Electronic Science and Technology of China
Chuan He, University of Electronic Science and Technology of China
Manxi He, University of Electronic Science and Technology of China
Jing Du, University of Electronic Science and Technology of China
Bharat B. Biswal, University of Electronic Science and Technology of China
Dezhong Yao, University of Electronic Science and Technology of China
Gang Yao, University of Electronic Science and Technology of China
Mingjun Duan, University of Electronic Science and Technology of China

Document Type

Article

Publication Date

8-5-2021

Abstract

Schizophrenia is currently thought as a disorder with dysfunctional communication within and between sensory and cognitive processes. It has been hypothesized that these deficits mediate heterogeneous and comprehensive schizophrenia symptomatology. In this study, we investigated as to how the abnormal dynamic functional architecture of sensory and cognitive networks may contribute to these symptoms in schizophrenia. We calculated a sliding-window-based dynamic functional connectivity strength (FCS) and amplitude of low-frequency fluctuation (ALFF) maps. Then, using group-independent component analysis, we characterized spatial organization of dynamic functional network (sDFN) across various time windows. The spatial architectures of FCS/ALFF-sDFN were similar with traditional resting-state functional networks and cannot be accounted by length of the sliding window. Moreover, schizophrenic subjects demonstrated reduced dynamic functional connectivity (dFC) within sensory and perceptual sDFNs, as well as decreased connectivity between these sDFNs and high-order frontal sDFNs. The severity of patients' positive and total symptoms was related to these abnormal dFCs. Our findings revealed that the sDFN during rest might form the intrinsic functional architecture and functional changes associated with psychotic symptom deficit. Our results support the hypothesis that the dynamic functional network may influence the aberrant sensory and cognitive function in schizophrenia, further highlighting that targeting perceptual deficits could extend our understanding of the pathophysiology of schizophrenia.

Identifier

85113170931 (Scopus)

Publication Title

Frontiers in Psychiatry

External Full Text Location

https://doi.org/10.3389/fpsyt.2021.687580

e-ISSN

16640640

Volume

12

Grant

Q19028

Fund Ref

Sichuan Province Science and Technology Support Program

Recommended Citation

He, Hui; Luo, Cheng; He, Chuan; He, Manxi; Du, Jing; Biswal, Bharat B.; Yao, Dezhong; Yao, Gang; and Duan, Mingjun, "Altered Spatial Organization of Dynamic Functional Network Associates With Deficient Sensory and Perceptual Network in Schizophrenia" (2021). Faculty Publications. 3889.
https://digitalcommons.njit.edu/fac_pubs/3889