"Decellularized tissues as platforms for digestive system cancer models" by Zahra Seifi, Mozafar Khazaei et al.
 

Decellularized tissues as platforms for digestive system cancer models

Document Type

Article

Publication Date

6-15-2024

Abstract

The extracellular matrix (ECM) is a multifunctional network of macromolecules that regulate various cellular functions and physically support the tissues. Besides physiological conditions, the ECM also changes during pathological conditions such as cancer. As tumor cells proliferate, notable changes occur in the quantity and makeup of the surrounding ECM. Therefore, the role of this noncellular component of tissues in studies of tumor microenvironments should be considered. So far, many attempts have been made to create 2-dimensional (2D) or 3-dimensional (3D) models that can replicate the intricate connections within the tumor microenvironment. Decellularized tissues are proper scaffolds that imitate the complex nature of native ECM. This review aims to summarize 3D models of digestive system cancers based on decellularized ECMs. These ECM-based scaffolds will enable us to study the interactive communication between cells and their surrounding environment which brings new potential for a better understanding of the pathophysiology of cancer.

Identifier

85193821674 (Scopus)

Publication Title

Heliyon

External Full Text Location

https://doi.org/10.1016/j.heliyon.2024.e31589

ISSN

24058440

Issue

11

Volume

10

Fund Ref

Kermanshah University of Medical Sciences

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