Mapping circuit dynamics during function and dysfunction
Document Type
Article
Publication Date
3-1-2022
Abstract
Neural circuits can generate many spike patterns, but only some are functional. The study of how circuits generate and maintain functional dynamics is hindered by a poverty of description of circuit dynamics across functional and dysfunctional states. For example, although the regular oscillation of a central pattern generator is well characterized by its frequency and the phase relationships between its neurons, these metrics are ineffective descriptors of the irregular and aperiodic dynamics that circuits can generate under perturbation or in disease states. By recording the circuit dynamics of the well-studied pyloric circuit in Cancer borealis, we used statistical features of spike times from neurons in the circuit to visualize the spike patterns generated by this circuit under a variety of conditions. This approach captures both the variability of functional rhythms and the diversity of atypical dynamics in a single map. Clusters in the map identify qualitatively different spike patterns hinting at different dynamical states in the circuit. State probability and the statistics of the transitions between states varied with environmental perturbations, removal of descending neuromodulatory inputs, and the addition of exogenous neuromodulators. This analysis reveals strong mechanistically interpretable links between complex changes in the collective behavior of a neural circuit and specific experimental manipulations, and can constrain hypotheses of how circuits generate functional dynamics despite variability in circuit architecture and environmental perturbations.
Identifier
85128488972 (Scopus)
Publication Title
Elife
External Full Text Location
https://doi.org/10.7554/eLife.76579
e-ISSN
2050084X
PubMed ID
35302489
Volume
11
Grant
N MH060605
Fund Ref
National Institutes of Health
Recommended Citation
Gorur-Shandilya, Srinivas; Cronin, Elizabeth M.; Schneider, Anna C.; Haddad, Sara Ann; Rosenbaum, Philipp; Bucher, Dirk; Nadim, Farzan; and Marder, Eve, "Mapping circuit dynamics during function and dysfunction" (2022). Faculty Publications. 3075.
https://digitalcommons.njit.edu/fac_pubs/3075
