"Development of nano structured graphene oxide incorporated dexamethaso" by Mohammad Saiful Islam and Somenath Mitra
 

Development of nano structured graphene oxide incorporated dexamethasone with enhanced dissolution

Document Type

Article

Publication Date

3-1-2022

Abstract

We present the development of nanographene oxide (nGO) incorporated dexamethasone (DXM) composites (DXM-nGO) with enhanced aqueous solubility. Antisolvent precipitation was used for successful incorporation of nGO into DXM, a popular COVID-19 drug. The study focuses on morphology and dissolution performance of the formulated DXM-nGO, which were characterized using scanning electron microscopy (SEM), Raman spectroscopy, X-ray diffraction (XRD), Differential scanning calorimetry (DSC) and Thermogravimetric analysis (TGA). In vitro dissolution profile showed that for a DXM-nGO containing 0.5% nGO showed that time for 50% dissolution (T50) dropped from 39 min to 24 min, while time for 80% dissolution (T80) went from not dissolved state to 56 min for the same composite. In general, the nGO incorporation into DXM showed enhanced solubility, and in vitro dissolution data suggest that the nGO may be a candidate for successful bioavailability improvement.

Identifier

85124291387 (Scopus)

Publication Title

Colloids and Interface Science Communications

External Full Text Location

https://doi.org/10.1016/j.colcom.2022.100599

e-ISSN

22150382

Volume

47

Grant

R01ES023209

Fund Ref

National Institute of Environmental Health Sciences

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