Hippocampus-based static functional connectivity mapping within white matter in mild cognitive impairment

Authors

Yuan Jiang, University of Electronic Science and Technology of China
Pan Wang, University of Electronic Science and Technology of China
Jiaping Wen, University of Electronic Science and Technology of China
Jianlin Wang, University of Electronic Science and Technology of China
Hongyi Li, Fourth People's Hospital of Chengdu
Bharat B. Biswal, University of Electronic Science and Technology of China

Document Type

Article

Publication Date

9-1-2022

Abstract

Mild cognitive impairment (MCI) is clinically characterized by memory loss and cognitive impairment closely associated with the hippocampal atrophy. Accumulating studies have confirmed the presence of neural signal changes within white matter (WM) in resting-state functional magnetic resonance imaging (fMRI). However, it remains unclear how abnormal hippocampus activity affects the WM regions in MCI. The current study employs 43 MCI, 71 very MCI (VMCI) and 87 age-, gender-, and education-matched healthy controls (HCs) from the public OASIS-3 dataset. Using the left and right hippocampus as seed points, we obtained the whole-brain functional connectivity (FC) maps for each subject. We then perform one-way ANOVA analysis to investigate the abnormal FC regions among HCs, VMCI, and MCI. We further performed probabilistic tracking to estimate whether the abnormal FC correspond to structural connectivity disruptions. Compared to HCs, MCI and VMCI groups exhibited reduced FC in the right middle temporal gyrus within gray matter, and right temporal pole, right inferior frontal gyrus within white matter. Specific dysconnectivity is shown in the cerebellum Crus II, left inferior temporal gyrus within gray matter, and right frontal gyrus within white matter. In addition, the fiber bundles connecting the left hippocampus and right temporal pole within white matter show abnormally increased mean diffusivity in MCI. The current study proposes a new functional imaging direction for exploring the mechanism of memory decline and pathophysiological mechanisms in different stages of Alzheimer’s disease.

Identifier

85134631587 (Scopus)

Publication Title

Brain Structure and Function

External Full Text Location

https://doi.org/10.1007/s00429-022-02521-x

e-ISSN

18632661

ISSN

18632653

PubMed ID

35864361

First Page

2285

Last Page

2297

Issue

7

Volume

227

Grant

61871420

Fund Ref

National Natural Science Foundation of China

Recommended Citation

Jiang, Yuan; Wang, Pan; Wen, Jiaping; Wang, Jianlin; Li, Hongyi; and Biswal, Bharat B., "Hippocampus-based static functional connectivity mapping within white matter in mild cognitive impairment" (2022). Faculty Publications. 2686.
https://digitalcommons.njit.edu/fac_pubs/2686