Entrainment within hierarchical circadian oscillator networks
Document Type
Article
Publication Date
9-1-2022
Abstract
Circadian rhythms are endogenous oscillations, widely found across biological species, that have the capability of entraining to the 24-h light-dark cycle. Circadian systems often consist of both central oscillators that receive direct light-dark input and peripheral oscillators that receive input from the central oscillators. In this paper, we address questions related to what governs the time to and pattern of entrainment of these hierarchical circadian systems after an abrupt switch in the light-dark phasing. For a network consisting of a single central oscillator coupled to a chain of N feed-forward peripheral oscillators, we introduce a systematic way to derive an N-dimensional entrainment map whose fixed points correspond to entrained solutions. Using the map, we explain that the direction of reentrainment can involve fairly complicated phase advancing and delaying behavior as well as reentrainment times that depend sensitively on the nature of the perturbation. We also study the dynamics of a hierarchical system in which the peripheral oscillators are mutually coupled. We study how reentrainment times vary as a function of the degree to which the oscillators are desynchronized at the time of the change in light-dark phasing. We show that desynchronizing the peripheral oscillators can, in some circumstances, speed up their ultimate reentrainment following perturbations.
Identifier
85135916162 (Scopus)
Publication Title
Mathematical Biosciences
External Full Text Location
https://doi.org/10.1016/j.mbs.2022.108883
e-ISSN
18793134
ISSN
00255564
PubMed ID
35907509
Volume
351
Grant
KJQN201900619
Fund Ref
National Natural Science Foundation of China
Recommended Citation
Liao, Guangyuan and Bose, Amitabha, "Entrainment within hierarchical circadian oscillator networks" (2022). Faculty Publications. 2674.
https://digitalcommons.njit.edu/fac_pubs/2674
