Fluorescent Multifunctional Organic Nanoparticles for Drug Delivery and Bioimaging: A Tutorial Review
Document Type
Article
Publication Date
11-1-2022
Abstract
Fluorescent organic nanoparticles (FONs) are a large family of nanostructures constituted by organic components that emit light in different spectral regions upon excitation, due to the presence of organic fluorophores. FONs are of great interest for numerous biological and medical applications, due to their high tunability in terms of composition, morphology, surface functional-ization, and optical properties. Multifunctional FONs combine several functionalities in a single nanostructure (emission of light, carriers for drug-delivery, functionalization with targeting ligands, etc.), opening the possibility of using the same nanoparticle for diagnosis and therapy. The prepa-ration, characterization, and application of these multifunctional FONs require a multidisciplinary approach. In this review, we present FONs following a tutorial approach, with the aim of providing a general overview of the different aspects of the design, preparation, and characterization of FONs. The review encompasses the most common FONs developed to date, the description of the most important features of fluorophores that determine the optical properties of FONs, an overview of the preparation methods and of the optical characterization techniques, and the description of the theoretical approaches that are currently adopted for modeling FONs. The last part of the review is devoted to a non-exhaustive selection of some recent biomedical applications of FONs.
Identifier
85148533417 (Scopus)
Publication Title
Pharmaceutics
External Full Text Location
https://doi.org/10.3390/pharmaceutics14112498
e-ISSN
19994923
Issue
11
Volume
14
Grant
R21AA028340
Fund Ref
Ministerio de Ciencia e Innovación
Recommended Citation
Vargas-Nadal, Guillem; Köber, Mariana; Nsamela, Audrey; Terenziani, Francesca; Sissa, Cristina; Pescina, Silvia; Sonvico, Fabio; Gazzali, Amirah Mohd; Wahab, Habibah A.; Grisanti, Luca; Olivera, María Eugenia; Palena, María Celeste; Guzman, María Laura; Luciani-Giacobbe, Laura Carolina; Jimenez-Kairuz, Alvaro; Ventosa, Nora; Ratera, Imma; and Belfield, Kevin D., "Fluorescent Multifunctional Organic Nanoparticles for Drug Delivery and Bioimaging: A Tutorial Review" (2022). Faculty Publications. 2572.
https://digitalcommons.njit.edu/fac_pubs/2572
