Entropic interactions of 2D materials with cellular membranes: Parallel versus perpendicular approaching modes
Document Type
Article
Publication Date
11-1-2022
Abstract
Understanding the interaction of 2D materials including graphene, boron nitride and MoS2 with biological systems is a growing topic of interest to many applications such as biosensors, drug delivery, gene therapy and nano-toxicity. In this paper, we show that the interaction of 2D materials with cellular membranes at its early stage of approaching is dominantly controlled by entropic forces. Recent experiments indicate that graphene sheets, depending on their size, can either undergo a near-orthogonal cutting or a parallel attachment mode of interaction with cell membranes. Here, we perform a set of integrated theoretical statistical mechanics analysis and coarse-grained molecular dynamics simulations to quantify the entropic energy barrier for these modes of interactions. Our results indicate that micro-sized graphene sheets prefer approaching a fluctuating membrane through a sharp corner, while nano-sized sheets are more likely to adhere to the cell membrane surface due to relatively low entropic energy cost that is comparable with thermal energy from random Brownian motions.
Identifier
85137165413 (Scopus)
Publication Title
Mechanics of Materials
External Full Text Location
https://doi.org/10.1016/j.mechmat.2022.104414
ISSN
01676636
Volume
174
Grant
RG138/20
Fund Ref
Agency for Science, Technology and Research
Recommended Citation
Ahmadpoor, Fatemeh; Zou, Guijin; and Gao, Huajian, "Entropic interactions of 2D materials with cellular membranes: Parallel versus perpendicular approaching modes" (2022). Faculty Publications. 2564.
https://digitalcommons.njit.edu/fac_pubs/2564
