Spontaneously forming unilamellar phospholipid vesicles

Document Type

Conference Proceeding

Publication Date

12-1-2004

Abstract

Unilamellar vesicles (ULV) consisting of a single lipid bilayer are of special interest as drug delivery vehicles. Here, we report on a spontaneously forming ULV system composed of the short- and long-chain phospholipids, dihexanoyl (DHPC) and dimyristoyl (DMPC) phosphorylcholine, respectively, doped with the negatively charged lipid, dimyristoyl phosphorylglycerol (DMPG). Small-angle neutron scattering (SANS) and dynamic light scattering (DLS) were employed to systematically investigate the effects of lipid concentration, salinity, and time on vesicle stability. It is found that ULV size is practically constant over a range of lipid concentration and temperature. The spontaneously formed ULV are stable for periods of four months, or greater, without the use of stabilizers.

Identifier

13244298670 (Scopus)

Publication Title

Macromolecular Symposia

External Full Text Location

https://doi.org/10.1002/masy.200550111

ISSN

10221360

First Page

123

Last Page

134

Volume

219

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