Molecularly imprinted polymer-modified carbon paste electrodes (MIP-CPE): A review on sensitive electrochemical sensors for pharmaceutical determinations
Document Type
Article
Publication Date
3-1-2023
Abstract
Recent years have been associated with the development of various sensor-based technologies in response to the undeniable need for the rapid and precise analysis of an immense variety of pharmaceuticals. In this regard, special attention has been paid to the design and fabrication of sensing platforms based on electrochemical detection methods as they can offer many advantages, such as portability, ease of use, relatively cheap instruments, and fast response times. Carbon paste electrodes (CPEs) are among the most promising conductive electrodes due to their beneficial properties, including ease of electrode modification, facile surface renewability, low background currents, and the ability to modify with different analytes. However, their widespread use is affected by the lack of sufficient selectivity of CPEs. Molecularly imprinted polymers (MIPs) composed of tailor-made cavities for specific target molecules are appealing complementary additives that can overcome this limitation. Accordingly, adding MIP to the carbon paste matrix can contribute to the required selectivity of sensing platforms. This review aims to present a categorized report on the recent research and the outcomes in the combinatory fields of MIPs and CPEs for determining pharmaceuticals in complex and simple matrices. CPEs modified with MIPs of various pharmaceutical compounds, including analgesic drugs, antibiotics, antivirals, cardiovascular drugs, as well as therapeutic agents affecting the central nervous system (CNS), will be addressed in detail.
Identifier
85147540541 (Scopus)
Publication Title
Trac Trends in Analytical Chemistry
External Full Text Location
https://doi.org/10.1016/j.trac.2023.116949
e-ISSN
18793142
ISSN
01659936
Volume
160
Grant
43002620
Fund Ref
Shahid Beheshti University of Medical Sciences
Recommended Citation
Afsharara, Hanif; Asadian, Elham; Mostafiz, Bahar; Banan, Kamran; Bigdeli, Sara Arjomand; Hatamabadi, Dara; Keshavarz, Azadeh; Hussain, Chaudhery Mustansar; Keçili, Rüstem; and Ghorbani-Bidkorpeh, Fatemeh, "Molecularly imprinted polymer-modified carbon paste electrodes (MIP-CPE): A review on sensitive electrochemical sensors for pharmaceutical determinations" (2023). Faculty Publications. 1893.
https://digitalcommons.njit.edu/fac_pubs/1893
