Commenting on the effects of surface treated- and non-surface treated TiO2 in the Caco-2 cell model

Document Type

Letter to the Editor

Publication Date

11-12-2012

Abstract

In a recent work published in Particle and Fibre Toxicology by Fisichella and coworkers investigating surface-modified TiO2 nanoparticle exposure in a model human intestinal epithelium (Caco-2), albeit degraded to mimic conditions in the gut and exposure to natural sunlight, purportedly resulted in no toxic effects. The authors (Fisichella et al.) claim to have confirmed the results of a 2010 report by Koeneman et al. However, the study by Koeneman and colleagues revealed significant effects of unmodified TiO2 nanoparticles. These contradicting data warrant further investigation into the possible effects of aluminum hydroxide, as these nanoparticles appear to have resulted in an abnormal apical surface in Caco-2 cells. © 2012 Faust et al.; licensee BioMed Central Ltd.

Identifier

84868668525 (Scopus)

Publication Title

Particle and Fibre Toxicology

External Full Text Location

https://doi.org/10.1186/1743-8977-9-42

e-ISSN

17438977

PubMed ID

23146628

Volume

9

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