Genome-wide search for coaxial helical stacking motifs

Document Type

Conference Proceeding

Publication Date

12-1-2012

Abstract

Motif finding in DNA, RNA and proteins plays an important role in life science research. In this paper, we present a computational approach to searching for RNA tertiary motifs in genomic sequences. Specifically, we describe a method, named CSminer, and show, as a case study, the application of CSminer to genome-wide search for coaxial helical stackings in RNA 3-way junctions. A coaxial helical stacking motif occurs in an RNA 3-way junction where two separate helical elements form a pseudocontiguous helix and provide thermodynamic stability to the RNA molecule as a whole. Experimental results demonstrate the effectiveness of our approach. © 2012 IEEE.

Identifier

84872842701 (Scopus)

ISBN

[9781467343589]

Publication Title

IEEE 12th International Conference on Bioinformatics and Bioengineering Bibe 2012

External Full Text Location

https://doi.org/10.1109/BIBE.2012.6399685

First Page

260

Last Page

265

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