Teratogenicity of metals to chick embryos

Document Type

Article

Publication Date

5-1-1990

Abstract

The present study examines the effects of heavy metals on chick embryogenesis. The metals included were cadmium, arsenic, cobalt, copper, indium, iron, manganese, and molybdenum. Salts of each of the metals were dissolved in saline and injected into the air sacs on d 2 of incubation. Dose levels varied with the metal to be tested. Control eggs were injected with an equivalent volume of saline (0.1 ml/egg). On d 14, the live embryos were removed from the eggs and examined for gross malformations. From the LD50 values, the toxicity relationship between the metals is cadmium > arsenic > cobalt > copper > indium > molybdenum > manganese > iron. The LD50 values were 3, 9, 38, 58, 121, 333, 765, and 1185 ng/egg, respectively. The gross malformations observed were reduced body size, micromelia, twisted neck, hemorrhage, everted viscera, and microphthalmia. Arsenic and cobalt were observed to be more teratogenic than other metals. This study showed that the metals tested were both toxic and teratogenic to varying degrees in chick embryogenesis. © 1975 Taylor & Francis Group, LLC.

Identifier

0025353893 (Scopus)

Publication Title

Journal of Toxicology and Environmental Health

External Full Text Location

https://doi.org/10.1080/15287399009531407

ISSN

00984108

PubMed ID

2348478

First Page

23

Last Page

31

Issue

1

Volume

30

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