"HHFS: A Hybrid Hierarchical Feature Selection Method for Ageing Gene C" by Dehui Li, Quanwang Wu et al.
 

HHFS: A Hybrid Hierarchical Feature Selection Method for Ageing Gene Classification

Document Type

Article

Publication Date

6-1-2023

Abstract

As one of the most complicated processes in biological development, ageing remains poorly understood. These days more and more ageing-related gene data sets become available on the Web, where each instance is characterized by a set of hierarchically organized binary features. Traditional data mining methods show limitations in exploiting this hierarchical feature space. This article proposes a hybrid hierarchical feature selection (HHFS) method for classifying genes into prolongevity or anti-longevity ones. HHFS conducts lazy and eager feature selections sequentially, taking into account both uniqueness of a test instance and the whole characteristics of data sets. It adopts two complementary relevancy metrics (i.e., Gini purity and mutual information) to remove hierarchical redundancy. The experiments are conducted based on the ageing-related gene data of four model organisms. The results show that HHFS achieves significantly better prediction performance than several state-of-the-art methods.

Identifier

85131764367 (Scopus)

Publication Title

IEEE Transactions on Cognitive and Developmental Systems

External Full Text Location

https://doi.org/10.1109/TCDS.2022.3176548

e-ISSN

23798939

ISSN

23798920

First Page

690

Last Page

699

Issue

2

Volume

15

Grant

62072060

Fund Ref

National Natural Science Foundation of China

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