Identifying the distinct spectral dynamics of laminar-specific interhemispheric connectivity with bilateral line-scanning fMRI
Document Type
Article
Publication Date
7-1-2023
Abstract
Despite extensive efforts to identify interhemispheric functional connectivity (FC) with resting-state (rs-) fMRI, correlated low-frequency rs-fMRI signal fluctuation across homotopic cortices originates from multiple sources. It remains challenging to differentiate circuit-specific FC from global regulation. Here, we developed a bilateral line-scanning fMRI method to detect laminar-specific rs-fMRI signals from homologous forepaw somatosensory cortices with high spatial and temporal resolution in rat brains. Based on spectral coherence analysis, two distinct bilateral fluctuation spectral features were identified: ultra-slow fluctuation (<0.04 Hz) across all cortical laminae versus Layer (L) 2/3-specific evoked BOLD at 0.05 Hz based on 4 s on/16 s off block design and resting-state fluctuations at 0.08–0.1 Hz. Based on the measurements of evoked BOLD signal at corpus callosum (CC), this L2/3-specific 0.05 Hz signal is likely associated with neuronal circuit-specific activity driven by the callosal projection, which dampened ultra-slow oscillation less than 0.04 Hz. Also, the rs-fMRI power variability clustering analysis showed that the appearance of L2/3-specific 0.08–0.1 Hz signal fluctuation is independent of the ultra-slow oscillation across different trials. Thus, distinct laminar-specific bilateral FC patterns at different frequency ranges can be identified by the bilateral line-scanning fMRI method.
Identifier
85148632109 (Scopus)
Publication Title
Journal of Cerebral Blood Flow and Metabolism
External Full Text Location
https://doi.org/10.1177/0271678X231158434
e-ISSN
15597016
ISSN
0271678X
PubMed ID
36803280
First Page
1115
Last Page
1129
Issue
7
Volume
43
Grant
2123971
Fund Ref
National Science Foundation
Recommended Citation
Choi, Sangcheon; Chen, Yi; Zeng, Hang; Biswal, Bharat; and Yu, Xin, "Identifying the distinct spectral dynamics of laminar-specific interhemispheric connectivity with bilateral line-scanning fMRI" (2023). Faculty Publications. 1621.
https://digitalcommons.njit.edu/fac_pubs/1621