Modified ecarin clotting time test monitors the anticoagulant effects of hirudin

Document Type

Article

Publication Date

1-1-1999

Abstract

A rapid blood clotting test for monitoring the thrombin inhibiting activity of the drug hirudin is described. This test, a modified ecarin clotting time, may enable the monitoring of a patient's hirudin dosage so that a safe, therapeutic level is achieved. The results show that there was an increase in clotting time with an increased level of hirudin. The data demonstrates a linear correlation between ecarin clotting time prolongation and hirudin content. Each clotting time is significantly prolonged (p<0.01) in comparison to the clotting time at lower concentrations.

Identifier

0032688809 (Scopus)

Publication Title

Bioengineering Proceedings of the Northeast Conference

First Page

100

Last Page

101

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