Designing RNA structures: Natural and artificial selection

Document Type

Conference Proceeding

Publication Date

1-1-2002

Abstract

Nature has wide latitude to select among messenger RNA (mRNA) sequences which are informationally equivalent, but structurally and energetically divergent. In this work, an attempt is made to explore how nature takes advantage of this freedom, and how to algorithmically design structures more energetically favorable than have been built through natural selection. Experimental results are discussed, placing the high/low stability sequences in context with both wildtype and random encodings.

Identifier

0036376063 (Scopus)

Publication Title

Proceedings of the Annual International Conference on Computational Molecular Biology RECOMB

First Page

109

Last Page

116

This document is currently not available here.

Share

COinS