The influences of Ih on temporal summation in hippocampal CA1 pyramidal neurons: A modeling study

Document Type

Article

Publication Date

1-1-2003

Abstract

Recent experimental and theoretical studies have found that active dendritic ionic currents can compensate for the effects of electrotonic attenuation. In particular, temporal summation, the percentage increase in peak somatic voltage responses invoked by a synaptic input train, is independent of location of the synaptic input in hippocampal CA1 pyramidal neurons under normal conditions. This independence, known as normalization of temporal summation, is destroyed when the hyperpolarization-activated current, Ih, is blocked [Magee JC (1999a), Nature Neurosci. 2: 508-514]. Using a compartmental model derived from morphological recordings of hippocampal CA1 pyramidal neurons, we examined the hypothesis that Ih was primarily responsible for normalization of temporal summation. We concluded that this hypothesis was incomplete. With a model that included Ih, the persistent Na+ current (INaP), and the transient A-type K+ current (IA), however, we observed normalization of temporal summation across a wide range of synaptic input frequencies, in keeping with experimental observations.

Identifier

0242288886 (Scopus)

Publication Title

Journal of Computational Neuroscience

External Full Text Location

https://doi.org/10.1023/A:1025881007453

ISSN

09295313

PubMed ID

14512744

First Page

131

Last Page

142

Issue

2

Volume

15

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