Transitions in the model of epithelial patterning

Document Type

Article

Publication Date

1-1-2003

Abstract

We analyze pattern formation in the model of cell communication in Drosophila egg development. The model describes the regulatory network formed by the epidermal growth factor receptor (EGFR) and its ligands. The network is activated by the oocyte-derived input that is modulated by feedback loops within the follicular epithelium. We analyze these dynamics within the framework of a recently proposed mathematical model of EGFR signaling (Shvartsman et al. [2002] Development 129:2577-2589). The emphasis is on the large-amplitude solutions of the model that can be correlated with the experimentally observed patterns of protein and gene expression. Our analysis of transitions between the major classes of patterns in the model can be used to interpret the experimentally observed phenotypic transitions in eggshell morphology in Drosophila melanogaster. The existence of complex patterns in the model can be used to account for complex eggshell morphologies in related fly species. © 2002 Wiley-Liss, Inc.

Identifier

12244309057 (Scopus)

Publication Title

Developmental Dynamics

External Full Text Location

https://doi.org/10.1002/dvdy.10218

ISSN

10588388

PubMed ID

12508238

First Page

155

Last Page

159

Issue

1

Volume

226

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