Computational modeling of drug delivery by microvascular networks
Document Type
Conference Proceeding
Publication Date
1-1-2003
Abstract
We have previously developed general computational models for studying blood flow and oxygen transport in complex microvascular networks. Here we describe how these models can be used to study delivery of other chemical species such as therapeutic drugs. We first describe our model of microvascular blood flow and a three-dimensional, time-dependent transport model applicable when the species of interest is carried mainly in dissolved form in the blood and the systemic concentration is fixed. We then present results of numerical simulations of blood flow in a constructed three-dimensional capillary network. Finally, we perform simulations of mass transport in the network and present results indicating the spatial heterogeneity of the concentration in the tissue.
Identifier
84864393449 (Scopus)
Publication Title
Proceedings of the IEEE Annual Northeast Bioengineering Conference Nebec
e-ISSN
21607001
ISSN
1071121X
First Page
321
Last Page
322
Recommended Citation
Goldman, D., "Computational modeling of drug delivery by microvascular networks" (2003). Faculty Publications. 14360.
https://digitalcommons.njit.edu/fac_pubs/14360