Individual differences in time-varying and stationary brain connectivity during movie watching from childhood to early adulthood: Age, sex, and behavioral associations
Document Type
Article
Publication Date
10-1-2023
Abstract
Spatially remote brain regions exhibit dynamic functional interactions across various task conditions. While time-varying functional connectivity during movie watching shows sensitivity to movie content, stationary functional connectivity remains relatively stable across videos. These findings suggest that dynamic and stationary functional interactions may represent different aspects of brain function. However, the relationship between individual differences in time-varying and stationary connectivity and behavioral phenotypes remains elusive. To address this gap, we analyzed an open-access functional MRI dataset comprising participants aged 5–22 years, who watched two cartoon movie clips. We calculated regional brain activity, time-varying connectivity, and stationary connectivity, examining associations with age, sex, and behavioral assessments. Model comparison revealed that time-varying connectivity was more sensitive to age and sex effects compared with stationary connectivity. The preferred age models exhibited quadratic log age or quadratic age effects, indicative of inverted-U shaped developmental patterns. In addition, females showed higher consistency in regional brain activity and time-varying connectivity than males. However, in terms of behavioral predictions, only stationary connectivity demonstrated the ability to predict full-scale intelligence quotient. These findings suggest that individual differences in time-varying and stationary connectivity may capture distinct aspects of behavioral phenotypes.
Identifier
85171684791 (Scopus)
Publication Title
Developmental Cognitive Neuroscience
External Full Text Location
https://doi.org/10.1016/j.dcn.2023.101280
e-ISSN
18789307
ISSN
18789293
PubMed ID
37480715
Volume
63
Grant
R01MH131335
Fund Ref
National Institute of Mental Health
Recommended Citation
Di, Xin; Xu, Ting; Uddin, Lucina Q.; and Biswal, Bharat B., "Individual differences in time-varying and stationary brain connectivity during movie watching from childhood to early adulthood: Age, sex, and behavioral associations" (2023). Faculty Publications. 1412.
https://digitalcommons.njit.edu/fac_pubs/1412
