Far-red BODIPY-based oxime esters: photo-uncaging and drug delivery

Authors

Zhaoxiong Wan, New Jersey Institute of Technology
Shupei Yu, New Jersey Institute of Technology
Qi Wang, New Jersey Institute of Technology
Karthik Sambath, New Jersey Institute of Technology
Roshena Harty, New Jersey Institute of Technology
Xiangshan Liu, New Jersey Institute of Technology
Hao Chen, New Jersey Institute of Technology
Chen Wang, Queens College, City University of New York
Xuan Liu, Newark College of Engineering
Yuanwei Zhang, New Jersey Institute of Technology

Document Type

Article

Publication Date

10-18-2023

Abstract

Far-red BODIPY-based oxime esters for photo-uncaging were designed to release molecules of interest with carboxylic acids. The low power red LED light breaks the N-O oxime ester bond and frees the caged molecules. We studied the mechanism and kinetics of the uncaging procedure using a ¹H NMR spectrometer. Moreover, the drug delivery strategy to release valproic acid (VPA) on demand was tested in vitro using this far-red BODIPY photo-uncaging strategy to induce apoptosis in tumor cells.

Identifier

85175267835 (Scopus)

Publication Title

Journal of Materials Chemistry B

External Full Text Location

https://doi.org/10.1039/d3tb01867a

e-ISSN

20507518

ISSN

2050750X

PubMed ID

37850246

First Page

9889

Last Page

9893

Issue

41

Volume

11

Grant

1R15GM148990-01

Fund Ref

National Institutes of Health

Recommended Citation

Wan, Zhaoxiong; Yu, Shupei; Wang, Qi; Sambath, Karthik; Harty, Roshena; Liu, Xiangshan; Chen, Hao; Wang, Chen; Liu, Xuan; and Zhang, Yuanwei, "Far-red BODIPY-based oxime esters: photo-uncaging and drug delivery" (2023). Faculty Publications. 1379.
https://digitalcommons.njit.edu/fac_pubs/1379