Cooling crystallization of paracetamol in hollow fiber devices

Document Type

Article

Publication Date

5-9-2007

Abstract

We examine here cooling crystallization of aqueous paracetamol solutions in hollow fiber devices. It is shown that a solid hollow fiber crystallizer (SHFC)-static mixer assembly can be operated successfully up to 30-40°C below the metastable zone limit. Such a capability is not existent in industrial cooling crystallizers; it allows the decoupling of nucleation and growth, an opportunity offered currently only by impinging jet mixers for antisolvent crystallization. In addition, it leads to the achievement of very high nucleation rates and hence small crystal sizes. The former were 2-4 orders of magnitude higher than values previously obtained in solid hollow fiber crystallizers for potassium nitrate and salicylic acid and reached values encountered only in impinging jet crystallization. A qualitative comparison with existing literature data showed that the SHFC-static mixer combination confined the crystal size distribution (CSD) to smaller sizes and a narrower range. Finally, a linear relationship between the mean crystal size and the cooling medium temperature was observed. This relationship is indicative of the simplicity available in SHFCs vis-à-vis CSD control. © 2007 American Chemical Society.

Identifier

34249108508 (Scopus)

Publication Title

Industrial and Engineering Chemistry Research

External Full Text Location

https://doi.org/10.1021/ie060433w

ISSN

08885885

First Page

2928

Last Page

2935

Issue

10

Volume

46

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