"Influence of particle z-potential and experimental procedure on protei" by Aida López Ruiz, Mengyuan Xiao et al.
 

Influence of particle z-potential and experimental procedure on protein corona formation and multicomponent aggregation

Document Type

Article

Publication Date

12-1-2023

Abstract

Drug delivery systems have renewed attention in recent years to achieve targeted delivery while decreasing toxic side effects. However, there are many factors that prevent optimal administration of drug delivery particles. For instance, protein corona formation and aggregation both decrease the circulation half-life of drug delivery particles, leading to sequestration to the liver and spleen. Therefore, optimal surface modifications are needed to decrease protein corona formation and avoid aggregation. In this work, polystyrene particles were modified with multi-arm and linear polyethylene glycol (PEG) to determine their aggregation profiles and protein corona formation. Multi-arm PEGs were found to aggregate more than linear PEGs, due to the change in zeta potential from unreacted end groups, which may lead to shorter circulation half-lives. Furthermore, the protein corona formation and composition were studied after different washing procedures, highlighting the importance of studying protein corona formation with undiluted blood plasma.

Identifier

85170527278 (Scopus)

Publication Title

Aiche Journal

External Full Text Location

https://doi.org/10.1002/aic.18237

e-ISSN

15475905

ISSN

00011541

Issue

12

Volume

69

Grant

CHE‐2203284

Fund Ref

National Science Foundation

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