Detection and selective destruction of breast cancer cells

Authors

Yan Xiao, National Institute of Standards and Technology
Xiugong Gao, Research and Development
Oleh Taratula, Rutgers University-Newark
Stephen Treado, National Institute of Standards and Technology
Aaron Urbas, National Institute of Standards and Technology
R. David Holbrook, National Institute of Standards and Technology
Richard E. Cavicchi, National Institute of Standards and Technology
C. Thomas Avedisian, Cornell University College of Engineering
Somenath Mitra, New Jersey Institute of Technology
Ronak Savla, Rutgers University-Newark
Paul D. Wagner, National Cancer Institute (NCI)
Sudhir Srivastava, National Cancer Institute (NCI)
Huixin He, Rutgers University-Newark

Document Type

Syllabus

Publication Date

1-1-2011

Abstract

Nanocarrier-based antibody targeting is a promising modality in therapeutic and diagnostic oncology. Single-walled carbon nanotubes (SWNTs) exhibit two unique optical properties that can be exploited for these applications, strong Raman signal for cancer cell detection and near-infrared (NIR) absorbance for selective photothermal ablation of tumors. In the present study, we constructed a HER2 IgY-SWNT complex and demonstrated its dual functionality for both detection and selective destruction of cancer cells in an in vitro model consisting of HER2-expressing SK-BR-3 cells, and HER2-negative MCF-7 cells.

Identifier

85059577554 (Scopus)

ISBN

[9781926692739, 9781466558465]

Publication Title

Recent Advances in Nanotechnology

First Page

108

Last Page

123

Recommended Citation

Xiao, Yan; Gao, Xiugong; Taratula, Oleh; Treado, Stephen; Urbas, Aaron; Holbrook, R. David; Cavicchi, Richard E.; Avedisian, C. Thomas; Mitra, Somenath; Savla, Ronak; Wagner, Paul D.; Srivastava, Sudhir; and He, Huixin, "Detection and selective destruction of breast cancer cells" (2011). Faculty Publications. 11651.
https://digitalcommons.njit.edu/fac_pubs/11651