Effects of epidermal turnover on the dynamics of percutaneous drug absorption

Document Type

Article

Publication Date

1-1-2011

Abstract

A method was proposed to evaluate the effect of desquamation on the time to reach steady-state drug delivery rate and concentration in the skin layers. Evaluation of the effective time constant, in terms of key physicochemical properties of the system, does not require solving the fundamental equations. Laplace transforms and the residue theorem were applied to monitor the evolution of the medicament in the skin layers and subsequent uptake into the systemic circulation. The equilibrium flux and the effective time constant declined with increasing stratum corneum turnover velocity and were not affected by the speed at which cells in the viable epidermis moved toward the surface of the skin. Ninety eight percent of the equilibrium penetration rate was reached after four time constants. This dynamic metric helped measure the extent to which high lipophilicity or molecular weight delayed percutaneous drug absorption. © 2010 Elsevier Inc.

Identifier

78650741619 (Scopus)

Publication Title

Mathematical Biosciences

External Full Text Location

https://doi.org/10.1016/j.mbs.2010.10.004

ISSN

00255564

PubMed ID

21040736

First Page

16

Last Page

21

Issue

1

Volume

229

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