A new systematic methodology to determine drug's solubility in polymer

Document Type

Conference Proceeding

Publication Date

8-23-2011

Abstract

The solubility of a drug in a polymeric excipient dictates the process window of hot-melt extrusion (HME) and product stability during storage. In this study, a new systematic methodology has been developed to experimentally measure the solubility of a model drug in a pharmaceutical grade polymer at different temperatures. A "phase diagram" was constructed and could be explored to design the HME process. Flory-Huggins interaction parameter (χ) was calculated by Tdissolution depression method based on the "phase diagram" and was used for thermodynamic solubility calculation.

Identifier

80051816043 (Scopus)

ISBN

[9781617829604]

Publication Title

Annual Technical Conference ANTEC Conference Proceedings

First Page

1354

Last Page

1359

Volume

2

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