Effects of screw configuration on the dissolution behavior of indomethacin in Eudragit® E PO solid disperisons

Document Type

Conference Proceeding

Publication Date

8-23-2011

Abstract

This experimental study examines the evolution of the extent of dissolution of the active pharmaceutical ingredient (API) indomethacin (INM) into the polymer excipient Eudragit® E PO (E PO) on four screw configurations. The Fourier transform infrared spectroscopy (FT-IR) results show that kneading blocks accelerate the complete dissolution process. It is concluded that the kneading blocks, which cause the processed stream to undergo chaotic laminar extensional flow and are crucial to laminar distributive mixing, may be the main necessary mixing elements for the full dissolution of the drug in the polymer melt.

Identifier

80051808088 (Scopus)

ISBN

[9781617829604]

Publication Title

Annual Technical Conference ANTEC Conference Proceedings

First Page

1201

Last Page

1205

Volume

2

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