Flux tracking in drug delivery

Document Type

Article

Publication Date

10-1-2011

Abstract

The dynamics of diffusive and stress-induced transport in polymeric delivery systems was investigated. Partial and ordinary differential equations were first written to describe drug release behaviors in Maxwell and Maxwell-Voigt materials. The time constants governing the flux and concentration responses of a permeating species were determined from a Laplace transform solution of the original model. A " tracking strategy" , based on the estimated characteristic times, was proposed to estimate the delivery rate and the concentration near the exit side of the membrane. The methodology was more efficient at times greater than the time constant and the prediction error decreased further as the process approached steady state. Numerical illustrations and comparisons made with published data show the effectiveness of the proposed approach in describing the influence of the Young modulus, viscosity and relaxation time on the transient regime. © 2011 Elsevier Inc.

Identifier

79957749625 (Scopus)

Publication Title

Applied Mathematical Modelling

External Full Text Location

https://doi.org/10.1016/j.apm.2011.03.035

ISSN

0307904X

First Page

4684

Last Page

4696

Issue

10

Volume

35

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