Asimplified neuronal model for the instigation and propagation of cortical spreading depression

Document Type

Article

Publication Date

12-1-2011

Abstract

In this paper, we construct a simplified neuronal model that is capable of simulating the instigation of cortical spreading depression (CSD) and propagation of a CSD wave. Our model is a simplification and extension of a single neuron model proposed in the literature for studying the instigation of CSD. Using the simplified neuronal model, we construct a network of these simplified neurons. This network model shows that the propagation of a CSD wave occurs naturally after it is instigated electrically or chemically. Although the model is simple, the speed of the CSD wave predicted by our model is consistent with experimentally observed values. Finally, our model allows us to investigate the effects of specific ion channels on the spread of a CSD wave. © 2011 Global Science Press.

Identifier

84867681531 (Scopus)

Publication Title

Advances in Applied Mathematics and Mechanics

External Full Text Location

https://doi.org/10.4208/aamm.10-m1052

e-ISSN

20751354

ISSN

20700733

First Page

759

Last Page

773

Issue

6

Volume

3

Grant

1022848

Fund Ref

National Science Foundation

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