Chronic recordings from the rat spinal cord descending tracts with microwires

Document Type

Conference Proceeding

Publication Date

12-26-2011

Abstract

This study investigated the feasibility of chronically recording descending signals from the rat spinal cord using microwire electrodes. Eight 25m diameter Pt-Ir microwires were implanted in the dorsolateral rubrospinal tract (RST) bilaterally at the c5 level in each of the four adult Long Evans rats trained for food reach-to-grasp task. Signal stability was assessed by calculating the signal-to-noise ratio (SNR) and mean signal amplitude during the four week recording period. The results of ANOVA did not suggest significant difference between sessions for any of the electrodes, indicating stability. Immunohistology suggested minimal tissue response to these microwires during the four week implant period. The results of this study show that microwire electrodes can be used for short-term chronic recordings of signals from the descending motor tracts in experimental animals. © 2011 IEEE.

Identifier

84862606664 (Scopus)

ISBN

[9781424441211]

Publication Title

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS

External Full Text Location

https://doi.org/10.1109/IEMBS.2011.6090821

ISSN

1557170X

PubMed ID

22254970

First Page

2993

Last Page

2996

Grant

R01NS072385

Fund Ref

National Institute of Neurological Disorders and Stroke

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