Mechanisms of neural reorganization in chronic stroke subjects after virtual reality training
Document Type
Conference Proceeding
Publication Date
12-26-2011
Abstract
This study investigates patterns of brain reorganization in chronic stroke subjects after two weeks of robot-assisted arm and hand training in virtual reality (VR). Four subjects were studied with event-related fMRI while doing simple paretic hand finger movements before (double baseline) and after training. Bilateral hand movements were recorded and used to provide real-time feedback to subjects during scanning to eliminate performance confounds on fMRI results. The kinematic parameters of each movement were also used in the general linear model with the BOLD signal to investigate training-induced changes in neuromotor coupling. Univariate analysis showed an increase in BOLD signal in the ipsilesional hemisphere in two subjects and a decrease in activity in the other two subjects. Seed voxel based functional connectivity analysis revealed an increase in connectivity between ipsilesional motor cortex and bilateral sensorimotor cortex during finger movements in all four subjects. Hemispheric laterality index values showed a tendency to decrease reflecting a reduction in the over-dominance of the contralesional hemisphere. The study is novel in terms of 1) tracking finger movement during a motor task in the scanner, 2) monitoring motor performance during the experiment and 3) giving online visual feedback of subjects' movement. This pilot study introduces a novel approach to study neural plasticity by combining measures of regional intensity, interregional interactions (using functional connectivity analysis and hemispheric laterality index), and modulation in the strength of neuromotor coupling. © 2011 IEEE.
Identifier
84861673006 (Scopus)
ISBN
[9781424441211]
Publication Title
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS
External Full Text Location
https://doi.org/10.1109/IEMBS.2011.6092002
ISSN
1557170X
PubMed ID
22256226
First Page
8118
Last Page
8121
Grant
K01HD059983
Fund Ref
National Institute of Child Health and Human Development
Recommended Citation
Saleh, S.; Bagce, H.; Qiu, Q.; Fluet, G.; Merians, A.; Adamovich, S.; and Tunik, E., "Mechanisms of neural reorganization in chronic stroke subjects after virtual reality training" (2011). Faculty Publications. 10952.
https://digitalcommons.njit.edu/fac_pubs/10952
