Cardiac Tissue Engineering

Document Type

Syllabus

Publication Date

1-1-2016

Abstract

The development of functional cardiac tissue in vitro for replacing damaged heart tissues and eventually improving heart function is considered as a promising approach. This chapter discusses ongoing research efforts toward ultimately developing functional cardiac replacement tissue. Current challenges include selection of a suitable and abundant cell source for constructing physiologic tissues, mimicking native anisotropic structure and function, providing appropriate biophysical stimulations, and developing vascularized tissues for better survival and integration in vivo. In addition, various in vitro models, which can be used for investigating cardiac development and pathologies as well as for high-throughput drug screening applications, are discussed. Various cell types considered for cardiac regeneration, including mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). Various strategies have been employed in developing 3D cardiac tissue constructs using numerous types of biomaterials including hydrogels, fibrous scaffolds, and cell-mediated or scaffold-free biomaterials.

Identifier

85050179417 (Scopus)

ISBN

[9783527338634, 9783527689934]

Publication Title

Tissue Engineering for Artificial Organs Regenerative Medicine Smart Diagnostics and Personalized Medicine

External Full Text Location

https://doi.org/10.1002/9783527689934.ch13

First Page

413

Last Page

443

Volume

2-2

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