Quantitative optical coherence elastography based on fiber-optic probe for in situ measurement of tissue mechanical properties

Document Type

Article

Publication Date

1-26-2016

Abstract

We developed a miniature quantitative optical coherence elastography (qOCE) instrument with an integrated Fabry-Perot force sensor, for in situ elasticity measurement of biological tissue. The technique has great potential for biomechanics modeling and clinical diagnosis. We designed the fiber-optic qOCE probe that was used to exert a compressive force to deform tissue at the tip of the probe. Using the space-division multiplexed optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to quantify the probe deformation that was proportional to the force applied, and to quantify the tissue deformation corresponding to the external stimulus. Simultaneous measurement of force and displacement allowed us to extract Young’s modulus of biological tissue. We experimentally calibrated our qOCE instrument, and validated its effectiveness on tissue mimicking phantoms and biological tissues.

Identifier

84961782686 (Scopus)

Publication Title

Biomedical Optics Express

External Full Text Location

https://doi.org/10.1364/BOE.7.000688

e-ISSN

21567085

First Page

688

Last Page

700

Issue

2

Volume

7

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