Assessment of Hyperacute Cerebral Ischemia Using Laser Speckle Contrast Imaging

Authors

Bochao Niu, University of Electronic Science and Technology of China
Guan Sihai, Southwest University for Nationalities
Hongyan Gong, University of Electronic Science and Technology of China
Peng Hu, University of Electronic Science and Technology of China
Pushti Shah, Newark College of Engineering
Xiqin Liu, University of Electronic Science and Technology of China
Yang Xia, University of Electronic Science and Technology of China
Dezhong Yao, University of Electronic Science and Technology of China
Benjamin Klugah-Brown, University of Electronic Science and Technology of China
Bharat Biswal, University of Electronic Science and Technology of China

Document Type

Article

Publication Date

11-1-2024

Abstract

Background: Accurate diagnosis of cerebral ischemia severity is crucial for clinical decision making. Laser speckle contrast imaging-based cerebral blood flow imaging can help assess the severity of cerebral ischemia by monitoring changes in blood flow. Method: In this study, we simulated hyperacute ischemia in rats, isolating arterial and venous flow-related signals from cortical vasculature. Pearson correlation was used to examine the correlation between damaged vessels. Granger causality analysis was used to investigate causality correlation in ischemic vessels. Results: Resting state analysis revealed a negative Pearson correlation between regional arteries and veins. Following cerebral ischemia induction, a positive artery-vein correlation emerged, which vanished after blood flow reperfusion. Granger causality analysis demonstrating enhanced causality coefficients for middle artery-vein pairs during occlusion, with a stronger left-right arterial effect than that of right-left, which persisted after reperfusion. Conclusions: These processing approaches amplify the understanding of cerebral ischemic images, promising potential future diagnostic advancements.

Identifier

85208771750 (Scopus)

Publication Title

Brain Connectivity

External Full Text Location

https://doi.org/10.1089/brain.2024.0026

e-ISSN

21580022

ISSN

21580014

PubMed ID

39291777

First Page

459

Last Page

470

Issue

9

Volume

14

Grant

NSFC82250410380

Fund Ref

National Natural Science Foundation of China

Recommended Citation

Niu, Bochao; Sihai, Guan; Gong, Hongyan; Hu, Peng; Shah, Pushti; Liu, Xiqin; Xia, Yang; Yao, Dezhong; Klugah-Brown, Benjamin; and Biswal, Bharat, "Assessment of Hyperacute Cerebral Ischemia Using Laser Speckle Contrast Imaging" (2024). Faculty Publications. 107.
https://digitalcommons.njit.edu/fac_pubs/107