A BODIPY-Based Water-Soluble Fluorescent Probe for Mitochondria Targeting

Authors

Binglin Sui, New Jersey Institute of Technology
Simon Tang, University of Central Florida
Adam W. Woodward, University of Central Florida
Bosung Kim, University of Central Florida
Kevin D. Belfield, New Jersey Institute of Technology

Document Type

Article

Publication Date

6-1-2016

Abstract

A water-soluble fluorescent mitochondrial targeting probe is reported. The probe bears a BODIPY-based fluorophore, two triphenylphosphonium (TPP) groups as mitochondrial targeting moieties, and two PEG groups to increase water solubility and enhance biocompatibility. As a mitochondria-selective fluorescent probe, the new BODIPY derivative exhibited many desirable properties, such as water solubility, high fluorescence quantum yield, solvent independent photophysical properties, pH insensitivity, good photostability, low cytotoxicity, and excellent mitochondrial targeting ability. Fluorescence microscopy colocalization experiments demonstrated the ability of this new probe to target mitochondria within living cells for bioimaging.

Identifier

84971261006 (Scopus)

Publication Title

European Journal of Organic Chemistry

External Full Text Location

https://doi.org/10.1002/ejoc.201600238

e-ISSN

10990690

ISSN

1434193X

First Page

2851

Last Page

2857

Issue

16

Volume

2016

Grant

CBET-1517273

Fund Ref

National Science Foundation

Recommended Citation

Sui, Binglin; Tang, Simon; Woodward, Adam W.; Kim, Bosung; and Belfield, Kevin D., "A BODIPY-Based Water-Soluble Fluorescent Probe for Mitochondria Targeting" (2016). Faculty Publications. 10469.
https://digitalcommons.njit.edu/fac_pubs/10469