Document Type
Dissertation
Date of Award
Spring 5-31-2008
Degree Name
Doctor of Philosophy in Mathematical Sciences - (Ph.D.)
Department
Mathematical Sciences
First Advisor
Amitabha Koshal Bose
Second Advisor
Farzan Nadim
Third Advisor
Jorge P. Golowasch
Fourth Advisor
Horacio G. Rotstein
Fifth Advisor
Georgi Medvedev
Abstract
This dissertation studies the roles of gap junctions in the dynamics of neuronal networks in three distinct problems. First, we study the circumstances under which a network of excitable cells coupled by gap junctions exhibits sustained activity. We investigate how network connectivity and refractory length affect the sustainment of activity in an abstract network. Second, we build a mathematical model for gap junctionally coupled cables to understand the voltage response along the cables as a function of cable diameter. For the coupled cables, as cable diameter increases, the electrotonic distance decreases, which cause the voltage to attenuate less, but the input of the second cable decreases, which allows the voltage of the second cable to attenuate more. Thus we show that there exists an optimal diameter for which the voltage amplitude in the second cable is maximized. Third, we investigate the dynamics of two gap-junctionally coupled theta neurons. A single theta neuron model is a canonical form of Type I neural oscillator that yields a very low frequency oscillation. The coupled system also yields a very low frequency oscillation in the sense that the ratio of two cells' spiking frequencies obtains the values from a very small number. Thus the network exhibits several types of solutions including stable suppressed and 1 N spiking solutions. Using phase plane analysis and Denjoy's Theorem, we show the existence of these solutions and investigate some of their properties.
Recommended Citation
Ha, Joon, "Roles of gap junctions in neuronal networks" (2008). Dissertations. 861.
https://digitalcommons.njit.edu/dissertations/861
