Document Type
Thesis
Date of Award
6-30-1970
Degree Name
Master of Science in Chemical Engineering - (M.S.)
Department
Chemical Engineering and Chemistry
First Advisor
Edward Charles Roche, Jr.
Second Advisor
John E. McCormick
Third Advisor
Dimitrios P. Tassios
Abstract
This thesis investigates the lyophilization of pharmaceuticals in vials by conductive heat transfer. The process phase diagram and methods of determining the solution eutectic temperature are reviewed. The theoretical considerations of heat and mass transfer pertaining to this process are discussed.
Lyophilization tests of distilled water and of mannitol solutions are used to indicate the relationship between vacuum chamber total pressure and the product/vial interface temperature. Experiments with 10% lactose solutions are used to determine the effect of shelf fluid temperature, product height and chamber vacuum on product/vial interface temperature. Test on a pharmaceutical product are used to confirm the relationship of shelf fluid temperature on product/vial interface temperature and drying rate.
The graphical data is used to demonstrate a method of selecting the proper process conditions for control of the lyophilization process.
Recommended Citation
Walsh, William Warren, "Heat and mass transfer in the lyophilizatiuon of pharmaceuticals in vials by conduction heating" (1970). Theses. 2565.
https://digitalcommons.njit.edu/theses/2565
