Document Type
Thesis
Date of Award
10-31-1991
Degree Name
Master of Science in Biomedical Engineering - (M.S.)
Department
Biomedical Engineering Committee
First Advisor
Peter Engler
Second Advisor
Swamy Laxminarayan
Third Advisor
Joseph J. McArdle
Fourth Advisor
David S. Kristol
Abstract
Mathematical modelling and computer simulations of neurons was presented by various researchers in the past. Computer simulations provide a time efficient and cost effective method to obtain required information about the physiological system. The objective of this project is to study the kinetics of calcium channels in hippocampal neurons. In an attempt to study the calcium channel activity we have developed a mathematical model for the CA3 region of the hippocampus and have analysed the calcium current noise obtained from the physiological recordings. The Simulation results had reproduced the action potential and activities of sodium and potassium channels, but did not reproduce the calcium channel activity. The fluctuation analysis of calcium channels indicated there are two different processes associated with the calcium channels in hippocampal neurons.
Recommended Citation
Jasthi, Prasad D., "Calcium channel dynamics in hippocampal neurons : simulation and physiological studies" (1991). Theses. 2510.
https://digitalcommons.njit.edu/theses/2510
