Document Type
Thesis
Date of Award
Spring 5-31-2012
Degree Name
Master of Science in Pharmaceutical Chemistry - (M.S.)
Department
Chemistry and Environmental Science
First Advisor
Haidong Huang
Second Advisor
Carol A. Venanzi
Third Advisor
Tamara M. Gund
Fourth Advisor
Edgardo Tabion Farinas
Abstract
S-Adenosyl-L-Methionine (SAM), which is involved in methyl group transfers, is the second most abundant coenzyme in the human body. It is made from adenosinetriphosphate (ATP) and methionine catalyzed by adenosyltransferase. Methyltransferases (MTs) transfer the activated methyl group from the sulfur center to a specific position in a variety of substrates, e.g., DNA, RNA, proteins, and secondary metabolites. Methyltransferases have been linked to various diseases, including cancer.
In recent years, more and more SAM analogues have been reported. These analogues show activities in biological target labeling. The purpose of this thesis is to design and synthesize new SAM analogues to inhibit cytosine DNA Methyltransferases in tumor cells. A series of target compounds was designed and synthesized in several steps from the starting material adenosine. The synthesis route has been divided into three parts: introduction of the nitrogen at the 5’ position, synthesis of aromatic aldehyde, and connection of these two compounds. More compounds with the same core structure will be designed and synthesized. The inhibition activities will be tested in future studies.
Recommended Citation
Wu, Shanshan, "Design and synthesis studies of new s-adenosyl-l-methionine analogues" (2012). Theses. 127.
https://digitalcommons.njit.edu/theses/127
