Document Type
Thesis
Date of Award
Spring 5-31-2008
Degree Name
Master of Science in Biomedical Engineering - (M.S.)
Department
Biomedical Engineering
First Advisor
Treena Livingston Arinzeh
Second Advisor
George Collins
Third Advisor
William Corson Hunter
Fourth Advisor
Michael Jaffe
Abstract
Electrospinning of bovine Type I collagen and Poly (L-lactic acid) produces blended nanofiber scaffolds that may have application in tissue engineering, wound dressing and drug delivery.
The goal of this research work was to produce and characterize blended nanofibers of a protein, collagen, and a synthetic polymer, poly (L-lactic acid). This study focuses on the in-depth analysis of the appearance of the structural relaxation occurring at the glass transition temperature of PLLA in the collagen-PLLA blended electrospun mats. It is speculated that occurrence of this thermal event is more prominent in PLLA with high molecular weight due to the presence of entanglements. It has also been demonstrated that electrospinning leads to the formation of an aligned microstructure of the chains but not a crystalline arrangement. In addition, morphological characterization of the collagen-PLLA nanofiber mats were performed using scanning electron microscope and transmission electron microscope in order to understand the structural features of the PLLA-collagen clectrospun blended filaments. A hypothesis has been developed on the solid state structure of the electrospun PLLA-collagen filament blends and also on the formation of sheath-core morphology in blended nanofibers.
Recommended Citation
Banerjee, Angana, "Thermal and morphological analysis of collagen-plla electrospun blends" (2008). Theses. 350.
https://digitalcommons.njit.edu/theses/350
